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《医学前沿(英文)》 2012年 第6卷 第1期 页码 41-47 doi: 10.1007/s11684-012-0175-9
Umbilical cord mesenchymal stem cells (MSCs) are a unique, accessible, and non-controversial source of early stem cells that can be readily manipulated. As the most common pluripotent cell, bone marrow-derived MSCs display limitations with the progress of stem cell therapy. By contrast, umbilical cord-derived cells, which have plentiful resources, are more accessible. However, several uncertain aspects, such as the effect of donor selection or culture conditions, long-term therapeutic effects, product consistency, and potential tumorigenicity, are the bottleneck in this clinical therapy. MSCs are predicted to undergo an unprecedented development in clinical treatment when a generally acknowledged criterion emerges. In the current paper, we highlight the application of umbilical cord-derived MSCs in skin therapies based on our previous studies, as well as the achievements of our peers in this field. This paper focuses on the strategies, challenges, and potential of this novel therapy.
关键词: umbilical cord mesenchymal stem cells cutaneous regeneration
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
《环境科学与工程前沿(英文)》 2011年 第5卷 第4期 页码 512-518 doi: 10.1007/s11783-011-0372-9
Bin Yu, Xiaosong Gu
《医学前沿(英文)》 2019年 第13卷 第2期 页码 131-137 doi: 10.1007/s11684-018-0642-z
关键词: spinal cord injury biomaterial extrinsic barrier intrinsic regeneration capacity
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
《医学前沿(英文)》 2011年 第5卷 第4期 页码 401-413 doi: 10.1007/s11684-011-0161-7
关键词: bone regeneration animal models translational strategies oral and maxillofacial region
SHI Mingheng, DU Bin, ZHAO Yun
《能源前沿(英文)》 2007年 第1卷 第1期 页码 85-90 doi: 10.1007/s11708-007-0008-8
关键词: desiccant air-conditioning regeneration process air-conditioning system energy regeneration
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
《机械工程前沿(英文)》 2020年 第15卷 第2期 页码 265-278 doi: 10.1007/s11465-019-0571-9
关键词: railway vehicle primary damper power regeneration ride comfort running safety
Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 237-249 doi: 10.1007/s11684-016-0464-9
Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.
关键词: inner ear cochlea hair cell regeneration Wnt Notch signaling pathways
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
《环境科学与工程前沿(英文)》 2008年 第2卷 第4期 页码 410-414 doi: 10.1007/s11783-008-0069-x
关键词: effluent volume acidic three-compartment weakly exchange
Sulfidation/regeneration multicycle testing of nickel-modified ZnFe
Wei LI, Jinju GUO, Jiejie HUANG, Jiaotao ZHAO
《化学科学与工程前沿(英文)》 2010年 第4卷 第4期 页码 435-440 doi: 10.1007/s11705-010-0506-9
关键词: hot gas desulphurization nickel-modified ZnFe2O4 sulfidation/regeneration
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
《医学前沿(英文)》 2019年 第13卷 第2期 页码 160-188 doi: 10.1007/s11684-018-0629-9
关键词: bone tissue engineering stem cell bone scaffold growth factor bone regeneration
付小兵
《中国工程科学》 2009年 第11卷 第10期 页码 122-128
组织再生是21世纪生物学和医学领域研究的重点和热点。在回顾再生医学研究历史的基础上,概要介绍了组织再生所涉及的关键科学问题、重大需求以及部分已经取得的重要进展,并对将来的发展进行了展望。
Regeneration of hair cells in the mammalian vestibular system
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《医学前沿(英文)》 2016年 第10卷 第2期 页码 143-151 doi: 10.1007/s11684-016-0451-1
Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animals to recover from hearing and balance deficits. Such regeneration does not occur efficiently in humans and other mammals. Thus, balance deficits become permanent and is a common sensory disorder all over the world. Since Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells after gentamicin-induced damage in mature mammals, significant efforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hair cell loss. Moreover, recently many strategies have been developed to promote the hair cell regeneration and subsequent functional recovery of the vestibular system, including manipulating the Wnt, Notch and Atoh1. This article provides an overview of the recent advances in hair cell regeneration in mammalian vestibular epithelia. Furthermore, this review highlights the current limitations of hair cell regeneration and provides the possible solutions to regenerate functional hair cells and to partially restore vestibular function.
《环境科学与工程前沿(英文)》 2022年 第16卷 第8期 doi: 10.1007/s11783-022-1524-9
• New method of mineralizing PFCs was proposed.
关键词: PFCs Molten sodium hydroxide Thermal degradation Activated carbon regeneration
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
《医学前沿(英文)》 2020年 第14卷 第3期 页码 262-272 doi: 10.1007/s11684-019-0717-5
Ling Dai, Xiang Gao, Zhihua Ye, Hanmin Li, Xin Yao, Dingbo Lu, Na Wu
《医学前沿(英文)》 2021年 第15卷 第3期 页码 495-505 doi: 10.1007/s11684-020-0790-9
关键词: hepatitis B virus-related liver failure traditional Chinese medicine liver regeneration liver regeneration microenvironment cytokines
标题 作者 时间 类型 操作
Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration
null
期刊论文
Migration of manganese and iron during the adsorption-regeneration cycles for arsenic removal
Fangfang CHANG, Jiuhui QU, Xu ZHAO, Wenjun LIU, Kun WU
期刊论文
biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration
Bin Yu, Xiaosong Gu
期刊论文
Bone regeneration by stem cell and tissue engineering in oral and maxillofacial region
Zhiyuan Zhang
期刊论文
Investigation on regeneration and energy storage characteristics of a solar liquid desiccant air-conditioning
SHI Mingheng, DU Bin, ZHAO Yun
期刊论文
Evaluation of power regeneration in primary suspension for a railway vehicle
Ruichen WANG, Zhiwei WANG
期刊论文
Electro-assisted regeneration of ion exchange resins
LIU Zhigang, WANG Ying, LI Yansheng, CHANG Hui
期刊论文
Sulfidation/regeneration multicycle testing of nickel-modified ZnFe
Wei LI, Jinju GUO, Jiejie HUANG, Jiaotao ZHAO
期刊论文
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
期刊论文
Thermal defluorination behaviors of PFOS, PFOA and PFBS during regeneration of activated carbon by molten
期刊论文
Evidence for lung repair and regeneration in humans: key stem cells and therapeutic functions of fibroblast
Xuran Chu, Chengshui Chen, Chaolei Chen, Jin-San Zhang, Saverio Bellusci, Xiaokun Li
期刊论文